反应详情

A mixture of 7-hydroxy-4-methylcoumarin (1.76 g, 0.01 mol), K2CO3 (2.8 g, 0.02 mol), Kl (0.166 g, 0.001 mol), propargyl bromide (1.78 g, 0.015 mol) and acetone (100 mL) was refluxed 10 h and hot filtered. The solvent was evaporated and the residue was crystallized by toluene. This yields 1.93 g of a product with the following characteristics: m.p.140-141° C.; 1H NMR (CDCl3) δ: 2.4 (s), 2.69 (m), 4.8 (s, 2H), 6.15-7.58 (m, 4H).

1. temperaturewas refluxed 10 h
2. customThe solvent was evaporated
3. customthe residue was crystallized by toluene