Diethyl methylmalonate → HCID 17941404, compound

HRID 396431Notes

Reaction equation

[C:1]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([Cl:18])[CH:12]=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][CH:20](C(OCC)=O)[C:21]([O:23]CC)=[O:22]>>[C:1]([C:9]1[NH:10][C:11]2[C:16]([C:17]=1[CH:20]([CH3:19])[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=[C:13]([Cl:18])[CH:12]=2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 11857Diethyl methylmalonate

HCID 23003423HCID 23003423, compound

Product 1

HCID 17941404HCID 17941404, compound

Procedure

The title compound was prepared according to the procedure described in step 4 of Example 2 (Method B) from 2-benzoyl-6-chloroindole (step 3 of Example 2, Method B) and diethyl methylmalonate.

Sources & evidence

ORD record: ord-3fa42fa95978444a9c642517a67d3abb
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06608070B1

Reaction notes

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