2-Bromoacetyl-1-methylimidazole hydrobromide → [6-Chloro-2-(1-methylimidazole-2-carbonyl)-1H-indol-3-yl]acetic Acid

HRID 396443Notes

Reaction equation

HRID 396443 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10]C)=[O:9])=[C:4]([NH:14][C:15](OCC)=O)[CH:3]=1.Br.BrC[C:23]([C:25]1[N:26]([CH3:30])[CH:27]=[CH:28][N:29]=1)=[O:24]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([C:6]([CH2:7][C:8]([OH:10])=[O:9])=[C:15]([C:23]([C:25]3[N:26]([CH3:30])[CH:27]=[CH:28][N:29]=3)=[O:24])[NH:14]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 220498402-Bromoacetyl-1-methylimidazole hydrobromideHCID 23003310Methyl trans-4-chloro-2-(ethoxycarbonylamino)cinnamate

Product 1

HCID 18542187[6-Chloro-2-(1-methylimidazole-2-carbonyl)-1H-indol-3-yl]acetic Acid

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 31 from methyl trans-4-chloro-2-(ethoxycarbonylamino)cinnamate (Example 31, step 1) and 2-bromoacetyl-1-methylimidazole hydrobromide.*

Sources & evidence

ORD record
ord-bb530a1ed0cf48999e00faa6b971a6a1
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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