[6-Chloro-2-(5-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[5-chloro-2-(5-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate

HRID 396471Notes

Reaction equation

HRID 396471 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14]S(C2C=CC=CC=2)(=O)=O)=[C:6]([CH:13]=1)/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10].ClC1C=C2C(C(CC(O)=O)=[C:30]([C:34]([C:36]3[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][N:37]=3)=[O:35])N2)=CC=1>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:13]=2)[NH:14][C:30]=1[C:34]([C:36]1[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][N:37]=1)=[O:35]

Participants

3

Reactant 2

HCID 9862268[6-Chloro-2-(5-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic AcidHCID 11187263Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate

Product 1

HCID 23003382Methyl[5-chloro-2-(5-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-5-chloro-2-(phenylsulfonylamino)cinnamate (Example 36, step 3) and 2-bromoacetyl-5-methylpyridine (Preparation is described in step 1 of Example 32).

Sources & evidence

ORD record
ord-26744c45b1164c5aa0aa314cf260ff72
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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