1-(4-Chloro-pyridin-2-yl)-ethanone → 2-Acetyl-4-(tert-butyldimethylsilyloxymethyl)pyridine

HRID 396480Notes

Reaction equation

HRID 396480 reaction equation
[Si:1]([O:8][CH2:9]C1C=CN=C(C#N)C=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:18]([C:21]1[CH:26]=[C:25](Cl)[CH:24]=[CH:23][N:22]=1)(=[O:20])[CH3:19]>>[C:18]([C:21]1[CH:26]=[C:25]([CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[CH:24]=[CH:23][N:22]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 130119861-(4-Chloro-pyridin-2-yl)-ethanoneHCID 145414484-(Tert-butyldimethylsilyloxymethyl)pyridinecarbonitrile

Product 1

HCID 230033972-Acetyl-4-(tert-butyldimethylsilyloxymethyl)pyridine

Procedure

The title compound was prepared from 4-(tert-butyldimethylsilyloxymethyl)pyridinecarbonitrile (A. Hadri et al., J. Heterocycl. Chem., 1993, 30, 631) according to the procedure for preparing 2-acetyl-4-chloropyridine described in Example 33.

Sources & evidence

ORD record
ord-f3be48cd045946b28da30988357d4806
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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