3,5-dimethylpyridine-2-carbonitrile → HCID 23003411, compound

HRID 396490Notes

Reaction equation

HRID 396490 reaction equation
CC1C(C#N)=NC=C(C)C=1.C(C1C=C(Cl)C=CN=1)(=O)C.Br.Br[CH2:23][C:24]([C:26]1[C:31]([CH3:32])=[CH:30][C:29]([CH3:33])=[CH:28][N:27]=1)=[O:25]>>[C:24]([C:26]1[C:31]([CH3:32])=[CH:30][C:29]([CH3:33])=[CH:28][N:27]=1)(=[O:25])[CH3:23]

Participants

4

Reactant 3

HCID 81672693,5-dimethylpyridine-2-carbonitrileHCID 130119861-(4-Chloro-pyridin-2-yl)-ethanoneHCID 23003480HCID 23003480, compound

Product 1

HCID 23003411HCID 23003411, compound

Procedure

The title compound was prepared from 3,5-dimethylpyridinecarbonitrile (K. Takahashi et al., J. Heterocycl. Chem., 1978, 15, 893) according to the procedure for preparing 2-acetyl-4-chloropyridine described in Example 33. 1H-NMR (CDCl3) δ: 8.32 (1H, s), 7.37 (1H, s), 2.69 (3H, s), 2.56 (3H, s), 2.36 (3H, s). 2-Bromoacetyl-3,5-dimethylpyridine hydrobromide:

Sources & evidence

ORD record
ord-daded8e4a70c45fe81c44b5c5c71b4ad
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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