Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate → methyl[5-chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetate

HRID 396491Notes

Reaction equation

HRID 396491 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14]S(C2C=CC=CC=2)(=O)=O)=[C:6]([CH:13]=1)/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10].Br[CH2:25][C:26]([C:28]1[C:33]([F:34])=[C:32]([CH2:35][CH3:36])[CH:31]=[CH:30][N:29]=1)=[O:27]>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:13]=2)[NH:14][C:25]=1[C:26]([C:28]1[C:33]([F:34])=[C:32]([CH2:35][CH3:36])[CH:31]=[CH:30][N:29]=1)=[O:27]

Participants

3

Reactant 2

HCID 11187263Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamateHCID 230034262-Bromoacetyl-4-ethyl-3-fluoropyridine

Product 1

HCID 23003366methyl[5-chloro-2-(4-ethyl-3-fluoropyridine-2-carbonyl)-1H-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-5-chloro-2-(penylsulfonylamino)cinnamate (Example 36, step 3) and 2-bromoacetyl-4-ethyl-3-fluoropyridine*.

Sources & evidence

ORD record
ord-c36dfc90731740c2ba34ed896f72c3d3
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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