Hydrogen Peroxide → HCID 23003412, compound

HRID 396492Notes

Reaction equation

HRID 396492 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[F:9])[CH3:2].[OH:10]O>C(O)(=O)C>[CH2:1]([C:3]1[CH:8]=[CH:7][N+:6]([O-:10])=[CH:5][C:4]=1[F:9])[CH3:2]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 179412704-Ethyl-3-fluoropyridine

Product 1

HCID 23003412HCID 23003412, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 4-ethyl-3-fluoropyridine (R. P. Dikinson et al., Bioorg. Med. Chem. Lett., 1996, 6, 2031, 28.51 g, 205.9 mmol) and 30% hydrogen peroxide (30 ml) in acetic acid (300 ml) was heated at reflux temperature for 3 h. After cooling to room temperature, the resulting mixture was concentrated. The residue was diluted in dichloromethane (300 ml) and dried (MgSO4). Removal of solvent gave 32.30 g (100%) of the title compound as an oil.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 h
  3. concentrationthe resulting mixture was concentrated
  4. additionThe residue was diluted in dichloromethane (300 ml)
  5. dry with materialdried (MgSO4)
  6. customRemoval of solvent

Sources & evidence

ORD record
ord-a31482cfa84f41f79352520aacc30225
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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