[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[5,6-dichloro-2-(4-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate

HRID 396502Notes

Reaction equation

HRID 396502 reaction equation
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH3:11])=[O:9])=[C:4]([NH:15]S(C2C=CC=CC=2)(=O)=O)[CH:3]=1.ClC1C=C2C(C(CC(O)=O)=[C:31]([C:35]([C:37]3[CH:42]=[C:41]([CH3:43])[CH:40]=[CH:39][N:38]=3)=[O:36])N2)=CC=1>>[CH3:11][O:10][C:8](=[O:9])[CH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[C:13]([Cl:14])[CH:12]=2)[NH:15][C:31]=1[C:35]([C:37]1[CH:42]=[C:41]([CH3:43])[CH:40]=[CH:39][N:38]=1)=[O:36]

Participants

3

Reactant 2

HCID 9862267[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic AcidHCID 15453706Methyl trans-4,5-dichloro-2-(phenylsulfonylamino)cinnamate

Product 1

HCID 23003546Methyl[5,6-dichloro-2-(4-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-4,5-dichloro-2-(phenylsulfonylamino)cinnamate (step 3) and 2-bromoacetyl-4-methylpyridine hydrobromide (Preparation is described in step 2 of Example 31).

Sources & evidence

ORD record
ord-2d083b93ba184b5cbc1de04825df0137
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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