[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[6-methoxy-2-(4-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate
Reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6](/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10])=[C:5]([NH:15]S(C2C=CC(C)=CC=2)(=O)=O)[CH:4]=1.ClC1C=C2C(C(CC(O)=O)=[C:32]([C:36]([C:38]3[CH:43]=[C:42]([CH3:44])[CH:41]=[CH:40][N:39]=3)=[O:37])N2)=CC=1>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:14][CH:13]=2)[NH:15][C:32]=1[C:36]([C:38]1[CH:43]=[C:42]([CH3:44])[CH:41]=[CH:40][N:39]=1)=[O:37]Participants
3
Procedure
The title compound was prepared according to the procedure described in Example 57 from methyl trans-4-methoxy-2-(p-toluenesulfonylamino)cinnamate (step 3) and 2-bromoacetyl-4-methylpyridine hydrobromide (Preparation is described in step 2 of Example 31).
Sources & evidence
- ORD record
- ord-9f108b98dd3e4b92a742e04d67b0a96e
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06608070B1
Reaction notes
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