[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[2-(4-methylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetate

HRID 396507Notes

Reaction equation

HRID 396507 reaction equation
C1(C)C=CC(S([NH:10][C:11]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][C:12]=2/[CH:13]=[CH:14]/[C:15]([O:17][CH3:18])=[O:16])(=O)=O)=CC=1.ClC1C=C2C(C(CC(O)=O)=[C:35]([C:39]([C:41]3[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][N:42]=3)=[O:40])N2)=CC=1>>[CH3:18][O:17][C:15](=[O:16])[CH2:14][C:13]1[C:12]2[C:11](=[CH:22][CH:21]=[C:20]([O:23][C:24]([F:25])([F:26])[F:27])[CH:19]=2)[NH:10][C:35]=1[C:39]([C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][N:42]=1)=[O:40]

Participants

3

Reactant 2

HCID 9862267[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic AcidHCID 23003398Methyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamate

Product 1

HCID 23003559Methyl[2-(4-methylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamate (step 2) and 2-bromoacetyl-4-methylpyridine hydrobromide (Preparation is described in step 2 of Example 31).

Sources & evidence

ORD record
ord-0a0aa0117281416da84ab4aa50ec1e1c
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

Loading…