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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 396507Generated: October 26, 2026

[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[2-(4-methylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetate

https://huagongshe.com/reaction/396507

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic AcidHCID 9862267—
ReactantMethyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamateHCID 23003398—
ProductMethyl[2-(4-methylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetateHCID 23003559—

Reaction Steps

The title compound was prepared according to the procedure described in Example 57 from methyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamate (step 2) and 2-bromoacetyl-4-methylpyridine hydrobromide (Preparation is described in step 2 of Example 31).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06608070B1
Source datasetuspto-grants-2003_08
ORD IDord-0a0aa0117281416da84ab4aa50ec1e1c
Source noteuspto-grants-2003_08