2-Bromoacetyl-4-ethylpyridine → Methyl[2-(4-ethylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetate

HRID 396508Notes

Reaction equation

HRID 396508 reaction equation
C1(C)C=CC(S([NH:10][C:11]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][C:12]=2/[CH:13]=[CH:14]/[C:15]([O:17][CH3:18])=[O:16])(=O)=O)=CC=1.Br[CH2:30][C:31]([C:33]1[CH:38]=[C:37]([CH2:39][CH3:40])[CH:36]=[CH:35][N:34]=1)=[O:32]>>[CH3:18][O:17][C:15](=[O:16])[CH2:14][C:13]1[C:12]2[C:11](=[CH:22][CH:21]=[C:20]([O:23][C:24]([F:25])([F:26])[F:27])[CH:19]=2)[NH:10][C:30]=1[C:31]([C:33]1[CH:38]=[C:37]([CH2:39][CH3:40])[CH:36]=[CH:35][N:34]=1)=[O:32]

Participants

3

Reactant 2

HCID 230032632-Bromoacetyl-4-ethylpyridineHCID 23003398Methyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamate

Product 1

HCID 23003375Methyl[2-(4-ethylpyridine-2-carbonyl)-5-trifluoromethoxy-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-2-p-toluenesulfonylamino-5-(trifluoromethoxy)cinnamate (step 2 of Example 145) and 2-bromoacetyl-4-ethylpyridine (Preparation is described in Example 57).

Sources & evidence

ORD record
ord-88e2dc5bfef94fd5999160405cf22f1c
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

Loading…