2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → Methyl[5-chloro-2-(4-trifluoromethoxybenzoyl)-1h-indol-3-yl]acetate

HRID 396518Notes

Reaction equation

HRID 396518 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14]S(C2C=CC=CC=2)(=O)=O)=[C:6]([CH:13]=1)/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10].[F:24][C:25]([F:38])([F:37])[O:26][C:27]1[CH:36]=[CH:35][C:30]([C:31](=[O:34])[CH2:32]Br)=[CH:29][CH:28]=1>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:13]=2)[NH:14][C:32]=1[C:31](=[O:34])[C:30]1[CH:35]=[CH:36][C:27]([O:26][C:25]([F:24])([F:37])[F:38])=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27786912-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-oneHCID 11187263Methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate

Product 1

HCID 23003325Methyl[5-chloro-2-(4-trifluoromethoxybenzoyl)-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 8 (Method B) from methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate (Example 36, step 3) and 4-(trifluoromethoxy)phenacyl bromide (Preparation is described in Example 189).

Sources & evidence

ORD record
ord-9f906dd3cc914af9b02b139e8ea2e55e
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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