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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 396518Generated: October 26, 2026

2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → Methyl[5-chloro-2-(4-trifluoromethoxybenzoyl)-1h-indol-3-yl]acetate

https://huagongshe.com/reaction/396518

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-oneHCID 2778691—
ReactantMethyl trans 5-chloro-2-(phenylsulfonylamino)cinnamateHCID 11187263—
ProductMethyl[5-chloro-2-(4-trifluoromethoxybenzoyl)-1h-indol-3-yl]acetateHCID 23003325—

Reaction Steps

The title compound was prepared according to the procedure described in Example 8 (Method B) from methyl trans 5-chloro-2-(phenylsulfonylamino)cinnamate (Example 36, step 3) and 4-(trifluoromethoxy)phenacyl bromide (Preparation is described in Example 189).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06608070B1
Source datasetuspto-grants-2003_08
ORD IDord-9f906dd3cc914af9b02b139e8ea2e55e
Source noteuspto-grants-2003_08