Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate → Methyl[6-chloro-2-[4-(methylsulfonylamino)benzoyl]-1h-indol-3-yl]acetate

HRID 396520Notes

Reaction equation

HRID 396520 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH3:11])=[O:9])=[C:4]([NH:14]S(C2C=CC=CC=2)(=O)=O)[CH:3]=1.[CH3:24][S:25]([NH:28][C:29]1[CH:38]=[CH:37][C:32]([C:33](=[O:36])[CH2:34]Br)=[CH:31][CH:30]=1)(=[O:27])=[O:26]>>[CH3:11][O:10][C:8](=[O:9])[CH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=2)[NH:14][C:34]=1[C:33](=[O:36])[C:32]1[CH:31]=[CH:30][C:29]([NH:28][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:38][CH:37]=1

Participants

3

Reactant 2

HCID 11371593Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamateHCID 15592151N-(4-(2-bromoacetyl)phenyl)methanesulfonamide

Product 1

HCID 23003240Methyl[6-chloro-2-[4-(methylsulfonylamino)benzoyl]-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 8 (Method B) from methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate (step 1 of Example 8, Method A) and 4-(methylsulfonylamino)phenacyl bromide*.

Sources & evidence

ORD record
ord-3695724a4550449891d0cd02ae51c460
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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