1-(4-Chloro-pyridin-2-yl)-ethanone → 2-Acetyl-4-[1-(tert-butyldimethylsilyloxy)ethyl]pyridine

HRID 396568Notes

Reaction equation

HRID 396568 reaction equation
[Si:1]([O:8][CH:9](C1C=CN=C(C#N)C=1)[CH3:10])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:19]([C:22]1[CH:27]=[C:26](Cl)[CH:25]=[CH:24][N:23]=1)(=[O:21])[CH3:20]>>[C:19]([C:22]1[CH:27]=[C:26]([CH:9]([O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[CH3:10])[CH:25]=[CH:24][N:23]=1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 130119861-(4-Chloro-pyridin-2-yl)-ethanoneHCID 230034084-[1-(tert-Butyldimethylsilyloxy)ethyl]-2-pyridinecarbonitrile

Product 1

HCID 230033192-Acetyl-4-[1-(tert-butyldimethylsilyloxy)ethyl]pyridine

Procedure

The title compound was prepared from 4-[1-(tert-butyldimethylsilyloxy)ethyl]-2-pyridinecarbonitrile according to the procedure for preparing 2-acetyl-4-chloropyridine described Example 33.

Sources & evidence

ORD record
ord-8011f74b46c341db845816c13b9aed65
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

Loading…