反应详情

Ex-59A: To a solution of 4′-hydroxy-3′,5′-dimethoxyacetophenone (1 g, 5.1 mmol) in N,N-dimethylformamide were added tert-butyldimethylsilyl chloride (1,15 g, 7.6 mmol) and imidazole (0.69 g, 10.2 mmol). The mixture was stirred at room temperature overnight. Upon quenching with 1 M sulfuric acid solution, the mixture was extracted with dichloromethane. The organic phase was washed with saturated sodium bicarbonate and brine. It was dried and evaporated. Water (2 mL) was added to the residue, and the precipitate was filtered out and dried over an oil pump to give 1.28 g (81%) of 3′,5′-dimethoxy-4′-(tert-butyldimethylsiloxy)acetophenone as a white solid, m.p. 90-92° C.

1. customUpon quenching with 1 M sulfuric acid solution
2. extractionthe mixture was extracted with dichloromethane
3. washThe organic phase was washed with saturated sodium bicarbonate and brine
4. customIt was dried
5. customevaporated
6. additionWater (2 mL) was added to the residue
7. filtrationthe precipitate was filtered out
8. customdried over an oil pump