Acrylonitrile → HCID 22725172, compound

HRID 396608Notes

Reaction equation

HRID 396608 reaction equation
[C:1](#[N:4])[CH:2]=[CH2:3].[C:5]1([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CCO>[C:5]1([CH:11]2[CH2:12][CH2:13][N:14]([CH2:3][CH2:2][C:1]#[N:4])[CH2:15][CH2:16]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 7855AcrylonitrileHCID 698734-Phenylpiperidine

Product 1

HCID 22725172HCID 22725172, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Acrylonitrile (3.1 mL, 44 mmol, 2.5 equiv) was added to a solution of 4-phenylpiperidine (3.0 g, 18 mmol, 1.0 equiv) in EtOH (40 mL) and the mixture was stirred at room temperature for 1.5 hours. The volatiles were removed to give 3.8 g of pure product (brown oil, 99%), which was characterized spectroscopically.

Workup

  1. customThe volatiles were removed

Sources & evidence

ORD record
ord-640e8de839f9400caf70d946b8a349b9
Source dataset
uspto-grants-2003_08
Patent number
US06608086B2

Reaction notes

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