反应详情

Pentanoyl chloride (10.8 g) was added dropwise to a mixture of anhydrous aluminium chloride (28.2 g) and 1-acetyl-2,3-dihydro-1H-indole (10 g) in 1,2-dichloroethane (100 mL) with mechanical stirring. The mixture was stirred at reflux for 16 hours, then cooled, then poured into ice-water. The mixture was extracted with dichloromethane. The extracts were washed with 1M aqueous sodium hydroxide, then dried over magnesium sulphate, then evaporated to give the title compound (10.3 g) as a dark gum.

1. temperatureat reflux for 16 hours
2. temperaturecooled
3. extractionThe mixture was extracted with dichloromethane
4. washThe extracts were washed with 1M aqueous sodium hydroxide
5. dry with materialdried over magnesium sulphate
6. customevaporated