反应详情

To a stirred solution of 3-bromophenol (25 g, 145 mmol) in acetic anhydride (14 ml) was added a few drop of sulfuric acid, and the mixture was stirred for 2 hours. The mixture was poured into a solution of NaHCO3 (1.3 g, 15.5 mmol) in water (160 ml). The whole was extracted with diethylether. The organic layer was washed with saturated NaHCO3 aqueous solution, brine, dried over MgSO4, and concentrated in vacuo. The residue was used for next reaction without purification. (31 g, 99% yield).

1. extractionThe whole was extracted with diethylether
2. washThe organic layer was washed with saturated NaHCO3 aqueous solution, brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe residue was used for next reaction without purification