3-Fluoro-4-sulfamoylphenylhydrazine hydrochloride → 2-Fluoro-4-[5-[4-(2-furyl)-3-methylphenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

HRID 396804Notes

Reaction equation

HRID 396804 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([NH:13][NH2:14])[CH:6]=[CH:7][C:8]=1[S:9](=[O:12])(=[O:11])[NH2:10].[F:15][C:16]([F:35])([F:34])[C:17](=O)[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:28][CH:29]=[CH:30][CH:31]=2)=[C:23]([CH3:32])[CH:22]=1)=O>>[F:2][C:3]1[CH:4]=[C:5]([N:13]2[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[O:28][CH:29]=[CH:30][CH:31]=4)=[C:23]([CH3:32])[CH:22]=3)=[CH:18][C:17]([C:16]([F:35])([F:15])[F:34])=[N:14]2)[CH:6]=[CH:7][C:8]=1[S:9]([NH2:10])(=[O:11])=[O:12]

Participants

3

Reactant 2

HCID 223166693-Fluoro-4-sulfamoylphenylhydrazine hydrochlorideHCID 223167484,4,4-Trifluoro-1-[4-(2-furyl)-3-methylphenyl]butane-1,3-dione

Product 1

HCID 223167952-Fluoro-4-[5-[4-(2-furyl)-3-methylphenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Procedure

The title compound was prepared according to the procedure of Example 60 using 3-fluoro-4-sulfamoylphenylhydrazine hydrochloride instead of 3-fluoro-4-(methylsulfonyl)phenylhydrazine hydrochloride and 4,4,4-trifluoro-1-[4-(2-furyl)-3-methylphenyl]butane-1,3-dione instead of 4,4,4-trifluoro-1-[4-(2-furyl)phenyl]butane-1,3-dione in step 2.

Sources & evidence

ORD record
ord-555bb7546e524a8ab45aa29bc2c4d847
Source dataset
uspto-grants-2003_08
Patent number
US06608095B2

Reaction notes

Loading…