反应详情

To a solution of 3-chloro-4-fluorobenzenesulfonyl chloride (2.29 g, 10 mmol) in methylene chloride (30 mL) was added 25% ammonium hydroxide (10 mL) at room temperature and the mixture was stirred for 1 hour. The solvent was removed in vacuo. The residue was redissolved in ethyl acetate (50 mL) and the whole washed with water and brine. After dried over MgSO4 and concentration in vacuo. The resulting solid was recrystallized from ether-hexane to give the title compound (1.429 g, 68.2% yield).

1. customThe solvent was removed in vacuo
2. dissolutionThe residue was redissolved in ethyl acetate (50 mL)
3. washthe whole washed with water and brine
4. dry with materialAfter dried over MgSO4 and concentration in vacuo
5. customThe resulting solid was recrystallized from ether-hexane