HRID396879

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)Nc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1

HCID983566

N-[[4-(Acetylamino)phenyl]sulfonyl]-L-phenylalanine

C17H18N2O5S

结构：CC(C)CN([C@@H](CCCCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1

HCID3013754

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCC[C@@H](C(=O)O)N(CC(C)C)S(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1

HCID508551

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from solid phase bound Nα-isobutyl-Nα-(4-nitrobenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine (step A) as described in general procedure Bb using Nα-(4-acetamidobenzenesulfonyl)-L-phenylalanine (400 mg, 1.2 mmol) which was prepared in step A of example 3. The final product was purified by preparative HPLC to yield 55 mg (60%) of the desired material.

WORKUP

后处理

customwas prepared in step A of example 3
customThe final product was purified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b2270c96c614a34a531edea8b1302df
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06608100B1
来源说明: uspto-grants-2003_08

反应 SMILES

[CH2:1]([N:5]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=1)(=[O:34])=[O:33])[C@H:6]([C:29]([OH:31])=[O:30])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](OCC1C2C=CC=CC=2C2C1=CC=CC=2)=[O:13])[CH:2]([CH3:4])[CH3:3].[C:44]([NH:47][C:48]1[CH:53]=[CH:52][C:51]([S:54]([NH:57][C@H:58](C(O)=O)[CH2:59][C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)(=[O:56])=[O:55])=[CH:50][CH:49]=1)(=[O:46])[CH3:45]>>[CH3:3][CH:2]([CH2:1][N:5]([S:32]([C:35]1[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=1)(=[O:33])=[O:34])[C@H:6]([C:29]([OH:31])=[O:30])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([C@@H:58]([NH:57][S:54]([C:51]1[CH:50]=[CH:49][C:48]([NH:47][C:44]([CH3:45])=[O:46])=[CH:53][CH:52]=1)(=[O:56])=[O:55])[CH2:59][C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1)=[O:13])[CH3:4]