(S)-2-(4-acetamidophenylsulfonamido)-3-phenylpropanoic acid → (2S)-6-[[(2S)-2-[(4-acetamidophenyl)sulfonylamino]-3-phenyl-propanoyl]amino]-2-[isobutyl-(4-nitrophenyl)sulfonyl-amino]hexanoic acid

Participants

Reaction Steps

The title compound was prepared from solid phase bound Nα-isobutyl-Nα-(4-nitrobenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine (step A) as described in general procedure Bb using Nα-(4-acetamidobenzenesulfonyl)-L-phenylalanine (400 mg, 1.2 mmol) which was prepared in step A of example 3. The final product was purified by preparative HPLC to yield 55 mg (60%) of the desired material.

Provenance & Evidence