反应详情

温度

0 °C

A suspension of 5.66 g of 1-acetyl-4-(2,5-difluorobenzoyl)-4-hydroxypiperidine in 10 ml of 6N hydrochloric acid was stirred at reflux, under nitrogen for 3.5 hrs. The reaction mixture was allowed to cool to 0° C. whereupon a solid separated. The solid was collected, washed with ice-cold acetone and dried to give 4.4 g (80%) of product, mp 191°-193° C.

1. temperatureat reflux, under nitrogen for 3.5 hrs
2. customseparated
3. customThe solid was collected
4. washwashed with ice-cold acetone
5. customdried