反应详情

To 0.88 g of 1-(1,3-dioxolan-2-ylmethyl)quinolin-2(1H)-one, 8.8 mL of a 90% aqueous trifluoroacetic acid solution was added, and the mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, thereto were added an aqueous saturated sodium hydrogen carbonate solution and ethyl acetate, and the mixture was stirred at room temperature for 30 minutes. The organic layer was separated, and the aqueous layer was extracted 5 times with ethyl acetate. The organic layer and an extract were combined, the resultant solution was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 0.55 g of (2-oxoquinolin-1(2H)-yl)acetaldehyde.

1. customThe solvent was removed under reduced pressure
2. additionwere added an aqueous saturated sodium hydrogen carbonate solution and ethyl acetate
3. stirringthe mixture was stirred at room temperature for 30 minutes
4. customThe organic layer was separated
5. extractionthe aqueous layer was extracted 5 times with ethyl acetate
6. dry with materialthe resultant solution was dried over anhydrous magnesium sulfate
7. customthe solvent was removed under reduced pressure