4-Chlorobenzaldehyde → HCID 22672650, compound

HRID 396970Notes

Reaction equation

[CH3:1][CH:2]([CH3:17])[CH2:3][N:4]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:6]=[CH:5]1.[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=[O:24])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]([C:5]2[N:4]([CH2:3][CH:2]([CH3:17])[CH3:1])[C:16]3[C:15]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[N:9]=[CH:8][C:7]=3[N:6]=2)[OH:24])=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 77264-Chlorobenzaldehyde

HCID 11424651Deaminoimiquimod

Product 1

HCID 22672650HCID 22672650, compound

Procedure

Using the method of Example 45, 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (2.5 g) was reacted with 4-chlorobenzaldehyde to provide 3.1 g of a yellow solid. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Sources & evidence

ORD record: ord-e6c8f21eac704222ae451dcd77e0eff8
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06608201B2

Reaction notes

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