反应详情

A solution of N-[2-(3-methoxyphenyl)ethyl]benzamide (1.530 g, 5.99 mmol) in phosphorous oxychloride (10 ml, 107.3 mmol) was refluxed under N2 for 24 hours. The cooled reaction mixture was then slowly added to ice-water (50 ml) with stirring, and basified to pH 10 with concentrated ammonia (60 ml). This was extracted with CHCl3 (4×25 ml), and the combined organic extracts were dried over MgSO4 then concentrated in vacuo to give 1.548 g (100% yield) of yellow oil.

1. customThe cooled reaction mixture
2. extractionThis was extracted with CHCl3 (4×25 ml)
3. dry with materialthe combined organic extracts were dried over MgSO4
4. concentrationthen concentrated in vacuo