Dichloromethane → HCID 18172447, compound

HRID 397093Notes

Reaction equation

HRID 397093 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=3)[CH2:11][CH2:10][N:9]2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:4][CH:3]=1.C(Cl)Cl>CO.C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[CH2:11][CH2:10][N:9]2[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 30246211-(4-Chlorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 18172447HCID 18172447, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared by analogy to Example 48 except that 1-(4-chloro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline was used instead of 6-methoxy-1-(4-methoxy-phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline, and neat CH2Cl2 to 10% MeOH/CH2Cl2 was used as eluent for flash chromatography purification.

Workup

  1. customwas used as eluent for flash chromatography purification

Sources & evidence

ORD record
ord-5796a6885d4a49c798dd8693a6a3383d
Source dataset
uspto-grants-2003_08
Patent number
US06608203B2

Reaction notes

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