Dichloromethane → HCID 18172462, compound

HRID 397098Notes

Reaction equation

HRID 397098 reaction equation
[I:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([N:8]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=O)=[CH:4][CH:3]=1.C(Cl)Cl>C(Cl)Cl.CO>[I:1][C:2]1[CH:26]=[CH:25][C:5]([CH:6]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH3:24])=[CH:20][CH:21]=3)[CH2:16][CH2:15][N:8]2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 18172408HCID 18172408, compound

Product 1

HCID 18172462HCID 18172462, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared by analogy to Preparation 65 except that 4-iodo-N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-benzamide was used instead of 4-methoxy-N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-benzamide, and the final residue was subjected to flash chromatography using a gradient from neat CH2Cl2 to CH2Cl2:MeOH 60:1.

Sources & evidence

ORD record
ord-133f96c801454927ab7d476cd4baa4ca
Source dataset
uspto-grants-2003_08
Patent number
US06608203B2

Reaction notes

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