反应详情

A mixture of ethyl 3-amino-2-[[(2′-cyanobiphenyl-4-yl)-methyl]amino]benzoate (1.61 g), ethyl isothiocyanate (1.5 ml) and ethanol (1 ml) was stirred at room temperature for 3 days. The reaction mixture was dissolved in ethyl acetate and the solution was washed with water, dried and concentrated to dryness to give crystals. Recrystallization from ethyl acetate-hexane afforded pale yellow crystals (1.92 g, 91%), m.p. 108-110° C.

1. washthe solution was washed with water
2. customdried
3. concentrationconcentrated to dryness
4. customto give crystals
5. customRecrystallization from ethyl acetate-hexane afforded pale yellow crystals (1.92 g, 91%), m.p. 108-110° C.