Trifluoromethanesulfonic acid → HCID 69363848, compound

Temperature

0 °C

A mixture of carbonic acid 4-methoxycarbonylamino-phenyl ester methyl ester (20.0 g, 88.8 mmol) and N-iodosuccinimide (23.8 g, 105.78 mmol) in acetonitrile (330 mL) was cooled to 0° C. (ice-bath). Trifluoromethanesulfonic acid (1.6 mL, 18.2 mmol) was added dropwise. The cooling bath was removed and the reaction stirred 72 h at room temperature. TLC showed the reaction was complete. The mixture was poured into 1M pH7 phosphate buffer, and washed with ethyl acetate. The phases were separated, the aqueous phase was extracted with ethyl acetate and the combined organic phases washed with 10% sodium thiosulfate solution, brine, dried over sodium sulfate and evaporated. The residue was purified by column chromatography on silica gel (500 g, 3:2 hexane/ethyl acetate eluant) to afford the product as an off-white solid (28.7 g, 92%), which was used without further purification. m.p. 106° C.

1. customThe cooling bath was removed
2. additionThe mixture was poured into 1M pH7 phosphate buffer
3. washwashed with ethyl acetate
4. customThe phases were separated
5. extractionthe aqueous phase was extracted with ethyl acetate
6. washthe combined organic phases washed with 10% sodium thiosulfate solution, brine
7. dry with materialdried over sodium sulfate
8. customevaporated
9. customThe residue was purified by column chromatography on silica gel (500 g, 3:2 hexane/ethyl acetate eluant)

ORD record

ord-f1852fa388e341519ee10bfcbd440cff

Source dataset

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06610685B2