Sodium Hydroxide → N-[6-[3-[4-(Diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine

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Reaction Steps

830 mg of N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]-2,2-dimethylglycine ethyl ester was dissolved in 10 ml of ethanol; 3.2 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 17 hours. After the ethanol was distilled off, 1 N hydrochloric acid was added to reach pH 4.5. The precipitated crystal was collected by filtration, washed with water and ethanol, and dried, to yield 610 mg of the title compound.

Provenance & Evidence