Butylamine → HCID 70025618, compound

HRID 397595Notes

Reaction equation

HRID 397595 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH:28]3[O:30][CH2:29]3)=[CH:22][CH:21]=2)[CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.[CH2:31]([NH2:35])[CH2:32][CH2:33][CH3:34]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH:28]([OH:30])[CH2:29][NH:35][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:24][CH:25]=2)[CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8007ButylamineHCID 12114669HCID 12114669, compound

Product 1

HCID 70025618HCID 70025618, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (4-methoxyphenyl)-(4-(2,3-epoxypropyloxy)phenyl)-1,2,3,4-tetrahydronaphth-1-yl-methane (400 mg, 0.01 mol), n-butyl amine (1.0 ml, 0.01 mol) and ethanol (10 ml) was refluxed for 8 hrs. Ethanol was distilled off and the residue was passed through basic alumina using benzene:ethyl acetate as the eluent. The solvent was distilled off yielding the required product. Yield 230 mg (48.93%).

Workup

  1. temperaturewas refluxed for 8 hrs
  2. distillationEthanol was distilled off
  3. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-ac0b4bfc357d46559060f3ffcbb07281
Source dataset
uspto-grants-2003_08
Patent number
US06610705B1

Reaction notes

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