Hydrochloric Acid → HCID 23000863, compound

HRID 397601Notes

Reaction equation

HRID 397601 reaction equation
C([S:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:19]([CH:21]2[CH2:23][CH2:22]2)=[O:20])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[CH2:7][CH2:6]1)(=O)C.[ClH:24]>C(O)C>[ClH:24].[CH:21]1([C:19]([CH:11]([N:8]2[CH2:7][CH2:6][CH:5]([SH:4])[CH2:10][CH2:9]2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[O:20])[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15462945HCID 15462945, compound

Product 1

HCID 23000863HCID 23000863, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.00 g (5.97 mmol) of the 4-acetylthio-1-(α-cyclopropylcarbonyl-2-fluorobenzyl)piperidine obtained in the above-described step (a) were dissolved in 50 ml of ethanol. An appropriate amount of a hydrogen chloride gas was blown through the resulting solution and the resulting mixture was allowed to stand overnight at room temperature. The solvent was then distilled off under reduced pressure. The residue was crystallized from diethyl ether, whereby 1.95 g of 1-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4-mercaptopiperidine hydrochloride were obtained as faintly brown crystals (yield: 99%).

Workup

  1. distillationThe solvent was then distilled off under reduced pressure
  2. customThe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-5f0a1cf11a6b42a5846f82b0466d1565
Source dataset
uspto-grants-2003_08
Patent number
US06610708B1

Reaction notes

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