Hydrochloric Acid → HCID 23000838, compound

HRID 397611Notes

Reaction equation

HRID 397611 reaction equation
[C:1](/[CH:4]=[C:5]1\[CH2:6][N:7](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:8][CH2:9][CH:10]\1[OH:11])([OH:3])=[O:2].[ClH:31]>C(O)CCC>[ClH:31].[CH2:1]([O:3][C:1](/[CH:4]=[C:5]1\[CH2:6][NH:7][CH2:8][CH2:9][CH:10]\1[OH:11])=[O:2])[CH2:4][CH2:5][CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23000823HCID 23000823, compound

Product 1

HCID 23000838HCID 23000838, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
60 °C

Procedure

50 ml of 1-butanol were added to 5.44 g (13.6 mmol) of (E)-3-carboxymethylidene-4-hydroxy-1-triphenylmethylpiperidine. Hydrogen chloride gas was blown through the resulting mixture, followed by stirring at 60° C. for 1 hour. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was washed with toluene, whereby 3.43 g (yield: 100%) of (E)-3-butoxycarbonylmethylidene-4-hydroxypiperidine hydrochloride were obtained as a white solid.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. washThe residue was washed with toluene

Sources & evidence

ORD record
ord-4acdd96f79164baeb9a706261846e5b5
Source dataset
uspto-grants-2003_08
Patent number
US06610708B1

Reaction notes

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