Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-Piperidone | HCID 33721 | — |
| 반응물 | 6-Fluoroindole | HCID 351278 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 11053072 | — |
반응 단계
A solution of 6-fluoroindole (2 g, 15 mmol) and 4-piperidone (3 g, 19.6 mmol) in 2 N solution of KOH in MeOH (60 mL) was stirred at reflux for 72 h. The mixture was concentrated to ¼ volume, diluted with H20 and filtered affording 2.5 g (77%) as a pale yellow solid: mp 202-204° C.; MS (APCI) m/z 217 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610712B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-220836493af94b11ad7e9d570f8a52ea |
| 출처 메모 | uspto-grants-2003_08 |