反应详情

A solution of 6-fluoroindole (2 g, 15 mmol) and 4-piperidone (3 g, 19.6 mmol) in 2 N solution of KOH in MeOH (60 mL) was stirred at reflux for 72 h. The mixture was concentrated to ¼ volume, diluted with H20 and filtered affording 2.5 g (77%) as a pale yellow solid: mp 202-204° C.; MS (APCI) m/z 217 [M+H]+.

1. temperatureat reflux for 72 h
2. concentrationThe mixture was concentrated
3. additiondiluted with H20
4. filtrationfiltered
5. customaffording 2.5 g (77%) as a pale yellow solid