Sodium Hydroxide → HCID 9817520, compound

HRID 397626Notes

Reaction equation

HRID 397626 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[N:16]/[NH:17][CH2:18][C:19]([O:21]CC)=[O:20])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[N:16]/[NH:17][CH2:18][C:19]([OH:21])=[O:20])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 140460895HCID 140460895, compound

Product 1

HCID 9817520HCID 9817520, compoundYield 70.77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A reaction as in Example 6 was carried out using 0.80 g (3.63 mmole) of compound prepared in Reference Example 1 and 0.63 g of ethylhydrazinoacetate as starting materials to obtain 0.98 g of white ethyl (E)-2-[3-cyclopentyloxy-4-methoxyphenylmethylene]hydrazinoacetate. The prepared ester compound was hydrolysed in the mixture of methanol and 1.0 N aqueous sodium hydroxide solution to afford 0.75 g (70.77%) of white title solid. m.p. 165° C. (decomposed) 1H NMR(DMSO-d6): 1.59(2H, m) 1.71(4H, m) 1.87(2H, m) 3.74(3H, s) 3.83(2H, brs) 4.77(1H,m) 6.90(1H, d J=8.5 Hz) 6.96(1H, dd, J=8.3, 1.7 Hz) 7.09(1H, d J=1.7 Hz) 7.57(1H, s)

Sources & evidence

ORD record
ord-cac6da4060d6466380632a06fb197afc
Source dataset
uspto-grants-2003_08
Patent number
US06610715B1

Reaction notes

Loading…