Sodium Hydroxide → HCID 9817520, compound

Participants

Reaction Steps

A reaction as in Example 6 was carried out using 0.80 g (3.63 mmole) of compound prepared in Reference Example 1 and 0.63 g of ethylhydrazinoacetate as starting materials to obtain 0.98 g of white ethyl (E)-2-[3-cyclopentyloxy-4-methoxyphenylmethylene]hydrazinoacetate. The prepared ester compound was hydrolysed in the mixture of methanol and 1.0 N aqueous sodium hydroxide solution to afford 0.75 g (70.77%) of white title solid. m.p. 165° C. (decomposed) 1H NMR(DMSO-d6): 1.59(2H, m) 1.71(4H, m) 1.87(2H, m) 3.74(3H, s) 3.83(2H, brs) 4.77(1H,m) 6.90(1H, d J=8.5 Hz) 6.96(1H, dd, J=8.3, 1.7 Hz) 7.09(1H, d J=1.7 Hz) 7.57(1H, s)

Provenance & Evidence