Hydrogen Bromide → HCID 23000775, compound

HRID 397641Notes

Reaction equation

HRID 397641 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[C:19]1[N:23]=[C:22]([CH2:24][C:25]2[CH:44]=[CH:43][C:28]([O:29][CH2:30][CH2:31][NH:32]C(=O)OCC3C=CC=CC=3)=[CH:27][CH:26]=2)[O:21][N:20]=1)(=[O:12])=[O:11].Br>C(O)(=O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[C:19]1[N:23]=[C:22]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([O:29][CH2:30][CH2:31][NH2:32])=[CH:43][CH:44]=2)[O:21][N:20]=1)(=[O:12])=[O:11]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 23000700HCID 23000700, compound

Product 1

HCID 23000775HCID 23000775, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared by a similar method to Example 27 from benzyl N-(2-[4-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)2-piperidyl]-1,2,4-oxadiazol-5-yl methyl)phenoxy]ethyl)carbamate [see Preparation 56] and 45% w/w hydrogen bromide in glacial acetic acid to afford 2-[4-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethyl)phenoxy]ethylamine as a white solid.

Sources & evidence

ORD record
ord-4c4845822fb04afaa1b421ce3425dd9d
Source dataset
uspto-grants-2003_08
Patent number
US06610707B1

Reaction notes

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