Hydrochloric Acid → 2-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride

HRID 397651Notes

Reaction equation

HRID 397651 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][C:13]1[CH:38]=[CH:37][C:16]([O:17][CH2:18][C:19]2[O:23][N:22]=[C:21]([C@@H:24]3[CH2:29][CH2:28][CH2:27][CH2:26][N:25]3C(OC(C)(C)C)=O)[N:20]=2)=[CH:15][CH:14]=1.[ClH:39]>>[ClH:39].[NH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][C@H:24]1[C:21]1[N:20]=[C:19]([CH2:18][O:17][C:16]2[CH:37]=[CH:38][C:13]([CH2:12][N:3]3[C:2](=[O:1])[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[C:4]3=[O:11])=[CH:14][CH:15]=2)[O:23][N:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57063716HCID 57063716, compound

Product 1

HCID 699488362-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride

Procedure

The title compound was prepared by the method of Preparation 7 from tert-butyl (2S)-2-[5-(4-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-phenoxymethyl)-1,2,4-oxadiazol-3-yl]-1-piperidinecarboxylate [see Preparation 14] and hydrogen chloride gas to afford 2-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride as a white solid.

Sources & evidence

ORD record
ord-59d8825975424d45aa7a0700d216465f
Source dataset
uspto-grants-2003_08
Patent number
US06610707B1

Reaction notes

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