Thionyl Chloride → Benzyl 3-[(chlorosulfonyl)methyl]piperidine-1-carboxylate
Reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH2:17][S:18]([OH:21])(=O)=[O:19])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>>[Cl:24][S:18]([CH2:17][CH:13]1[CH2:14][CH2:15][CH2:16][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:12]1)(=[O:21])=[O:19]Participants
3
Procedure
The title compound was prepared by the method of Preparation 58 from 1-[(benzyloxy)carbonyl]-3-piperidylmethanesulfonic acid [see Preparation 61]and thionyl chloride to afford benzyl 3-[(chlorosulfonyl)methyl]-1-piperidinecarboxylate as an oil.
Sources & evidence
- ORD record
- ord-d7f4afb515d04e3eb6d16f19603e12fc
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610707B1
Reaction notes
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