反应详情

Dess-Martin reagent (814 mg) was added to a stirred solution of (2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-hydroxypropyl)-2-piperidinecarboxamide (548 mg) [see Preparation 80) and triethylamine (0.89 ml) in dichloromethane (20 ml). The reaction mixture was stirred for 1 hr after which time the mixture was filtered through a pad of basic alumina and washed through with dichloromethane to afford (2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-oxopropyl)-2-piperidinecarboxamide (300 mg).

1. filtrationwas filtered through a pad of basic alumina
2. washwashed through with dichloromethane