3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)propanoic acid → tert-butyl 4-[3-[(Z)-[amino-[(2S)-1-(cyclohexylmethylsulfonyl)piperidin-2-yl]methylidene]amino]oxy-3-oxopropyl]piperazine-1-carboxylate

Participants

Reaction Steps

The title compound was prepared by a similar method to Preparation 5 from (Z)-(2S)-1-[cyclohexylmethylsulfonyl]-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 28] and 3-[4-(tert-butoxycarbonyl)piperazino]propanoic acid [see Preparation 90] to afford tert-butyl 4-(3-[((Z)-amino(2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidylmethylidene)amino]oxy-3-oxopropyl)-1-piperazinecarboxylate as a brown oil.

Provenance & Evidence