Hydrochloric Acid → HCID 178479742, compound

HRID 397807Notes

Reaction equation

HRID 397807 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=[O:11])=[CH:9][C:4]=2[NH:3][CH:2]=1.[ClH:13]>O.[Pd]>[ClH:13].[NH:1]1[C:5]2[CH2:6][CH2:7][CH:8]([C:10]([OH:12])=[O:11])[CH2:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 4594565-Benzimidazolecarboxylic acid

Product 1

HCID 178479742HCID 178479742, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A solution of benzimidazole-5-carboxylic acid (10 g, 62 mmol) in 1 N HCl (70 ml) and H2O (30 ml) was hydrogenated at 100 bar and 80° C. in the presence of 10% palladium on carbon (2.5 g) for 2 days. The mixture was filtered and the solvent was evaporated. The residue was stirred with acetone (100 ml) and the solid was isolated and dried. This afforded 10.6 g (79%) of 4,5,6,7-tetrahydro-1H-benzimidazole-5-carboxylic acid hydrochloride.

Workup

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated
  3. customthe solid was isolated
  4. customdried

Sources & evidence

ORD record
ord-0e41118dae7943c9ad37faec87eea573
Source dataset
uspto-grants-2003_08
Patent number
US06610721B2

Reaction notes

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