2-Chlorophenol → HCID 131724043, compound

HRID 397810Notes

Reaction equation

HRID 397810 reaction equation
[OH:1][CH2:2][CH:3]1[C:11]2[N:10]=[CH:9][N:8](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:7]=2[CH2:6][CH2:5][CH2:4]1.[Cl:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1O>>[ClH:31].[Cl:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[O:1][CH2:2][CH:3]1[C:11]2[N:10]=[CH:9][NH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 72452-ChlorophenolHCID 23512747HCID 23512747, compound

Product 1

HCID 131724043HCID 131724043, compound

Procedure

Using a procedure similar to that described in Example 22 and starting from 4-hydroxymethyl-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole (0.19 g, 0.48 mmol) and 2-chlorophenol (0.1 ml, 1 mmol) 20 mg (14%) of the title compound was obtained as a solid.

Sources & evidence

ORD record
ord-f6130dc02f034b808547381aee2851f6
Source dataset
uspto-grants-2003_08
Patent number
US06610721B2

Reaction notes

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