反应详情

2-Phenoxymethyl-2,3-dihydropyran-4-one (2.30 g, 11.3 mmol) was dissolved in ethyl acetate (150 ml). 10% Palladium on charcoal (400 mg) was added. The reaction mixture was hydrogenated until the reaction stopped. The catalyst was removed by filtration through a glas-filter. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (200 g), using ethyl acetate/heptane 1:1 as eluent, to give 1.36 g of 2-phenoxymethyltetrahydropyran-4-one.

1. customThe catalyst was removed by filtration through a glas-filter
2. customThe solvent was removed in vacuo
3. customThe crude product was purified by flash chromatography on silica (200 g)