2-(4-Chloro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 3-(4-Chloro-3-trifluoromethyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

HRID 397881Notes

Reaction equation

HRID 397881 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])[CH:7]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19](B2OC(C)(C)C(C)(C)O2)=[CH:18][C:17]=1[C:31]([F:34])([F:33])[F:32]>>[ClH:15].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]3[CH:13]=[CH:12][N:11]=[C:10]3[CH3:14])[CH:7]=2)=[CH:18][C:17]=1[C:31]([F:32])([F:33])[F:34]

Participants

3

Reactant 2

HCID 177502382-(4-Chloro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 234449653-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

Product 1

HCID 234450513-(4-Chloro-3-trifluoromethyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

Procedure

The title compound, MS: m/e=352.3 (M+H+) was obtained as a beige foam (49% yield) by the reaction of 3-bromo-5-(2-methyl-imidazol-1-yl-methyl)-pyridine with 2-(4-chloro-3-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2] dioxaborolane.

Sources & evidence

ORD record
ord-3f901ff0844f49e38a2f77348cefa166
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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